Eduardo Salido Selected Research

glyoxylic acid (glyoxylate)

1/2021	Small Molecule-Based Enzyme Inhibitors in the Treatment of Primary Hyperoxalurias.
1/2021	Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria.
12/2019	Patients with primary hyperoxaluria type 2 have significant morbidity and require careful follow-up.
12/2019	Generation of an induced pluripotent stem cell line (CIMAi001-A) from a compound heterozygous Primary Hyperoxaluria Type I (PH1) patient carrying p.G170R and p.R122* mutations in the AGXT gene.
1/2019	Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1.
12/2018	CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I.
1/2018	Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1.
4/2016	Glycolate Oxidase Is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I.
4/2016	Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.
1/2016	Caenorhabditis elegans AGXT-1 is a mitochondrial and temperature-adapted ortholog of peroxisomal human AGT1: New insights into between-species divergence in glyoxylate metabolism.

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Eduardo Salido Research Topics

Disease

21	Primary Hyperoxaluria (Oxaluria, Primary) 07/2022 - 03/2005
19	Neoplasms (Cancer) 06/2022 - 06/2002
13	Primary hyperoxaluria type 1 01/2019 - 06/2009
8	Renal Insufficiency (Renal Failure) 12/2019 - 03/2005
7	Chronic Renal Insufficiency 01/2021 - 01/2012
5	Hyperoxaluria (Oxaluria) 01/2021 - 05/2011
5	Nephrocalcinosis 12/2019 - 03/2012
4	Inborn Genetic Diseases (Disease, Hereditary) 11/2020 - 03/2012
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2019 - 01/2018
3	Diabetes Mellitus 11/2018 - 01/2015
3	Fibrosis (Cirrhosis) 05/2016 - 02/2012
3	Inflammation (Inflammations) 01/2016 - 01/2016
3	Urolithiasis 05/2014 - 05/2011
2	Non-alcoholic Fatty Liver Disease 01/2021 - 01/2016
2	Kidney Calculi (Kidney Stone) 01/2021 - 03/2012
2	Carcinogenesis 08/2016 - 06/2002
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2016 - 07/2006
2	Vascular Calcification 01/2015 - 01/2008
2	Lithiasis 01/2015 - 05/2014
2	Adenoma (Adenomas) 08/2014 - 02/2007
2	Focal Segmental Glomerulosclerosis (Glomerulosclerosis, Focal) 07/2011 - 10/2009
1	Pyruvate Kinase Deficiency of Red Cells 10/2021
1	Hemolytic Anemia 10/2021
1	Iron Overload 10/2021
1	Lung Neoplasms (Lung Cancer) 01/2021
1	COVID-19 01/2021
1	Glioblastoma (Glioblastoma Multiforme) 01/2021
1	Melanoma (Melanoma, Malignant) 12/2020
1	Hyperuricemia 01/2020
1	Gout 01/2020
1	Primary hyperoxaluria type 2 12/2019
1	Amyloidosis 01/2019
1	Kidney Diseases (Kidney Disease) 01/2018
1	Muscular Diseases (Myopathy) 01/2018
1	Acidosis 01/2018
1	Coinfection 10/2017
1	Dyslipidemias (Dyslipidemia) 01/2017
1	Hypertension (High Blood Pressure) 01/2017

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 06/2022 - 01/2008
18	Alanine-glyoxylate transaminase (alanine-glyoxylate aminotransferase)IBA 01/2019 - 06/2009
17	glyoxylic acid (glyoxylate)IBA 01/2021 - 06/2009
15	EnzymesIBA 12/2019 - 02/2007
14	OxalatesIBA 01/2021 - 03/2005
5	Calcium OxalateIBA 01/2018 - 03/2012
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2008
4	Amino Acids FDA Link 01/2021 - 01/2015
3	LigandsIBA 05/2022 - 02/2016
3	Messenger RNA (mRNA)IBA 01/2021 - 08/2014
3	Oxidoreductases (Dehydrogenase)IBA 11/2019 - 02/2016
3	quinone (benzoquinone)IBA 11/2019 - 02/2016
3	NAD (NADH)IBA 11/2019 - 02/2016
3	Molecular Chaperones (Chaperone, Molecular)IBA 01/2019 - 11/2011
3	glycollate oxidaseIBA 12/2018 - 04/2016
3	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 10/2007
2	AntibodiesIBA 01/2021 - 01/2008
2	Tacrolimus (Prograf)FDA LinkGeneric 11/2018 - 01/2015
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/2018 - 01/2015
2	Flavin-Adenine Dinucleotide (FAD)IBA 01/2017 - 02/2016
2	ProdrugsIBA 01/2017 - 02/2016
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2016 - 04/2013
2	CalciumIBA 01/2016 - 02/2004
2	LipidsIBA 01/2016 - 03/2011
2	CreatinineIBA 12/2015 - 07/2006
2	Vascular Cell Adhesion Molecule-1 (Vascular Cell Adhesion Molecule 1)IBA 01/2015 - 02/2012
2	prostaglandin R2 D-isomerase (prostaglandin D2 synthase)IBA 08/2014 - 02/2007
1	Pharmaceutical PreparationsIBA 07/2022
1	Leucine (L-Leucine)FDA Link 06/2022
1	AntioxidantsIBA 06/2022
1	Oxygen (Dioxygen)IBA 05/2022
1	Pyruvate KinaseIBA 10/2021
1	4,6-dinitro-o-cresol (DNOC)IBA 10/2021
1	FlavoproteinsIBA 10/2021
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 01/2021
1	VaccinesIBA 01/2021
1	Waste Products (Waste Product)IBA 01/2021
1	Nucleocapsid ProteinsIBA 01/2021
1	ChromatinIBA 01/2021
1	Aconitate Hydratase (Aconitase)IBA 12/2020
1	fluorocitrateIBA 12/2020
1	Xanthine OxidaseIBA 01/2020
1	Urate Oxidase (Uricase)IBA 01/2020
1	Uric Acid (Urate)IBA 01/2020
1	Prealbumin (Transthyretin)IBA 01/2019
1	Lactic Acid (Lactate)FDA LinkGeneric 01/2018
1	Mucin-1 (CA 15-3 Antigen)IBA 01/2018
1	Salicylic Acid (2 Hydroxybenzoic Acid)FDA LinkGeneric 01/2018
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 01/2018
1	AntigensIBA 10/2017
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 01/2017
1	Cytochrome P-450 CYP3AIBA 01/2017
1	Matrix Metalloproteinases (MMPs)IBA 08/2016

Therapy/Procedure

7	Therapeutics 05/2022 - 03/2005
4	Kidney Transplantation 12/2019 - 07/2006
2	Transplantation 04/2008 - 03/2005
1	Splenectomy 10/2021
1	Erythrocyte Transfusion 10/2021
1	Ligation 10/2021
1	Drug Therapy (Chemotherapy) 01/2021
1	Enzyme Therapy 01/2020
1	Liver Transplantation 12/2019